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Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. 1990
H Kestler, and
T Kodama, and
D Ringler, and
M Marthas, and
N Pedersen, and
A Lackner, and
D Regier, and
P Sehgal, and
M Daniel, and
N King
New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.
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