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1. The influence of insulin on rat liver membrane lipid composition, fluidity, some enzyme activities and asymmetry of microsomal phospholipids were investigated. 2. The total phospholipids and cholesterol were increased in microsomes and reduced in plasma membranes from insulin-treated rats. 3. Of all the investigated enzymes participating in the lipid metabolism, only the neutral sphingomyelinase activity was observed to be enhanced, whereas the ceramide-phosphatidylethanolamine (PE) synthetase and phospholipase A2 activities remained unchanged. 4. Insulin administration caused translocation of phosphatidylserine (PS) and PE to the outer leaflet and of phosphatidylinositol (PI) to the inner leaflet of microsomal membranes.
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
January 1978,
Enzyme,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
February 1974,
Chemistry and physics of lipids,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
April 1975,
Acta pharmacologica et toxicologica,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
March 1968,
Biochimica et biophysica acta,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
January 1970,
Bollettino della Societa italiana di biologia sperimentale,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
August 1968,
Gan,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
June 1969,
Biochemical pharmacology,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
June 1972,
Biochimica et biophysica acta,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
February 1993,
Xenobiotica; the fate of foreign compounds in biological systems,
D H Petkova, and
M N Nikolova, and
A B Momchilova-Pankova, and
K S Koumanov
April 1967,
The Journal of nutrition,
