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This immunocytochemical study of the pituitaries of the primitive actinopterygians, Acipenser transmontanus, Lepisosteus spatula, and Amia calva, showed a strict delineation between the hormonal fragments of proopiomelanocorticotropin (POMC) produced by corticotropes of the pars distalis and the melanotropes of the pars intermedia. Corticotropes were immunoreactive only for ACTH and not to either of the further degradation products, alpha-MSH or beta-endorphin. Melanotropes were shown to be immunoreactive to all three antisera but it is argued that immunoreactivity of melanotropes to ACTH antiserum is due to that antiserum's cross-reactivity with the cleavage product corticotropin-like intermediate peptide. The PAS positivity of both the corticotropes and the melanotropes of all three primitive fish argues for an ancient origin of a carbohydrate component of POMC and for its loss or reduction in teleosts where these cells are PAS negative.
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
January 1994,
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J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
November 1979,
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J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
January 1988,
Peptides,
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
October 1986,
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J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
June 1981,
Molecular and cellular endocrinology,
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
April 1998,
The Journal of experimental biology,
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
October 1978,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
January 1984,
Cell and tissue research,
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
October 1991,
General and comparative endocrinology,
J M Joss, and
R M Dores, and
J W Crim, and
M Beshaw
January 1995,
Folia histochemica et cytobiologica,
