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The function of histamine receptor H4R in the brain revealed by interaction partners. 2011

Aurelio A Moya-Garcia, and Carlos E Rodriguez, and Ian Morilla, and Francisca Sanchez-Jimenez, and Juan A G Ranea
Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, and CIBER de Enfermedades Raras (CIBERER), Valencia, Spain. amoyag@uma.es

The histamine H4 receptor is mainly expressed in haematopoietic cells, hence is linked to inflammatory and immune system conditions. It has been recently discovered that the receptor is expressed also in the mammalian central nervous system (CNS), but its role in the brain remains unclear. We address the potential functions of the histamine H4 receptor in the human brain using a 'guilty by association' logic, by close examination of protein-protein functional associations networks in the human proteome.

UI MeSH Term Description Entries
D011968 Receptors, Histamine Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action. Histamine Binding Sites,Histamine Receptors,Histamine Receptor,Binding Sites, Histamine,Receptor, Histamine,Sites, Histamine Binding
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000074040 Receptors, Histamine H4 G-Protein-coupled histamine receptors that are expressed primarily in BONE MARROW as well as in peripheral tissues and organs. They are expressed by immune cells that include EOSINOPHILS; T-CELLS; DENDRITIC CELLS; and MAST CELLS. H4 Receptors,Histamine H4 Receptor,Histamine H4 Receptors,H4 Receptor, Histamine,H4 Receptors, Histamine,Receptor, Histamine H4,Receptors, H4
D043562 Receptors, G-Protein-Coupled The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. G Protein Coupled Receptor,G-Protein-Coupled Receptor,G-Protein-Coupled Receptors,G Protein Coupled Receptors,Receptor, G-Protein-Coupled,Receptors, G Protein Coupled
D018100 Receptors, Histamine H3 A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5) H3 Receptor,Histamine H3 Receptors,H3 Receptors,Histamine H3 Receptor,H3 Receptor, Histamine,H3 Receptors, Histamine,Receptor, H3,Receptor, Histamine H3,Receptors, H3
D025941 Protein Interaction Mapping Methods for determining interaction between PROTEINS. Interaction Mapping, Protein,Interaction Mappings, Protein,Mapping, Protein Interaction,Mappings, Protein Interaction,Protein Interaction Mappings
D040901 Proteomics The systematic study of the complete complement of proteins (PROTEOME) of organisms. Peptidomics

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