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The effect of neuropeptide Y (NPY) on gastric acid secretion was investigated on an everted preparation of isolated rat stomach. Perfusion with synthetic NPY did not modify the basal secretion of gastric acid. However, NPY reduced dimethylphenylpiperazinium (DMPP)-stimulated acid secretion at concentrations insufficient to affect acid secretion stimulated by muscarine, histamine or gastrin. The decrease in acetylcholine (ACh) release from postganglionic cholinergic neurons by NPY is therefore considered to be responsible. Determination of NPY content by radioimmunoassay, in mucosal and muscular layers of the stomach, indicates that NPY possibly produces cholinergic inhibition under physiological levels. The present study suggests, therefore, that NPY has the ability to inhibit the release of ACh from postganglionic cholinergic neurons, thus producing a decrease in gastric acid secretion.
L H Tsai, and
J T Cheng
July 1990,
Experientia,
L H Tsai, and
J T Cheng
May 1993,
Digestive diseases and sciences,
L H Tsai, and
J T Cheng
April 1992,
Regulatory peptides,
L H Tsai, and
J T Cheng
April 1986,
European journal of pharmacology,
L H Tsai, and
J T Cheng
March 1987,
Naunyn-Schmiedeberg's archives of pharmacology,
L H Tsai, and
J T Cheng
November 2008,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
L H Tsai, and
J T Cheng
July 1988,
Brain research,
L H Tsai, and
J T Cheng
January 1999,
Advances in experimental medicine and biology,
L H Tsai, and
J T Cheng
January 1987,
Proceedings of the Western Pharmacology Society,
