The effect of memantine in harmaline-induced tremor and neurodegeneration. 2011

Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
Department of Neurology, Kocaeli University Medical School, Kocaeli, Turkey. pervin.iseri@gmail.com

Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims to investigate the anti-tremogenic and neuroprotective effects of memantine (NMDA receptor antagonist) on the harmaline model of transient action tremor. The effects of memantine were further compared with ethanol. Three separate groups of male Wistar rats were injected either with saline, ethanol (1.5 gr/kg), or memantine (5 mg/kg) 15 min prior to a single intraperitoneal injection of harmaline (20 mg/kg). Tremor and locomotion were evaluated by a custom-built tremor and locomotion analysis system. After 24 h of harmaline injection, cellular viability, and apoptosis were assessed using crystal violet staining, and caspase-3 immunostaining, respectively. Harmaline caused neuronal cell loss and caspase-3 mediated apoptosis in cerebellar granular and purkinje cells as well as the inferior olivary neurons. Despite a reduction in tremor intensity and duration with ethanol, this compound resulted in cell loss in cerebellum and olivary nucleus. Memantine exhibited neuroprotective efficacy on cerebellar and inferior olivary neurons albeit weaker anti-tremor effect compared to ethanol. In conclusion, anti-tremogenic and neuroprotective effects do not necessarily overlap. Memantine is a potential treatment for ET particularly given its neuroprotective efficacy.

UI MeSH Term Description Entries
D008297 Male Males
D008559 Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent. 1,3-Dimethyl-5-aminoadamantane,1-Amino-3,5-dimethyladamantane,Axura,D-145,D145,Ebixa,Memantin,Memantine Hydrochloride,Namenda,D 145
D009410 Nerve Degeneration Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. Neuron Degeneration,Degeneration, Nerve,Degeneration, Neuron,Degenerations, Nerve,Degenerations, Neuron,Nerve Degenerations,Neuron Degenerations
D009847 Olivary Nucleus A brainstem nuclear complex. in the hindbrain, also referred to as the olivary body. The olivary nuclear complex is a part of the MEDULLA OBLONGATA and the PONTINE TEGMENTUM. It is involved with motor control and is a major source of sensory input to the CEREBELLUM. Basal Nucleus, Olivary,Nucleus Basalis, Olivary,Olivary Body,Olivary Complex,Olivary Nuclei,Complex, Olivary,Nucleus, Olivary,Nucleus, Olivary Basal,Olivary Basal Nucleus,Olivary Bodies
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D006246 Harmaline A beta-carboline alkaloid isolated from seeds of PEGANUM. 3H-Pyrido(3,4-b)indole, 4,9-dihydro-7-methoxy-1-methyl-,Dihydroharmine,Harmidine
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014202 Tremor Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE. Action Tremor,Intention Tremor,Resting Tremor,Coarse Tremor,Continuous Tremor,Darkness Tremor,Fine Tremor,Intermittent Tremor,Involuntary Quiver,Massive Tremor,Passive Tremor,Persistent Tremor,Pill Rolling Tremor,Rest Tremor,Saturnine Tremor,Senile Tremor,Static Tremor,Tremor, Limb,Tremor, Muscle,Tremor, Neonatal,Tremor, Nerve,Tremor, Perioral,Tremor, Semirhythmic,Action Tremors,Coarse Tremors,Continuous Tremors,Darkness Tremors,Fine Tremors,Intention Tremors,Intermittent Tremors,Involuntary Quivers,Limb Tremor,Limb Tremors,Massive Tremors,Muscle Tremor,Muscle Tremors,Neonatal Tremor,Neonatal Tremors,Nerve Tremor,Nerve Tremors,Passive Tremors,Perioral Tremor,Perioral Tremors,Persistent Tremors,Pill Rolling Tremors,Quiver, Involuntary,Rest Tremors,Resting Tremors,Saturnine Tremors,Semirhythmic Tremor,Semirhythmic Tremors,Senile Tremors,Static Tremors,Tremor, Action,Tremor, Coarse,Tremor, Continuous,Tremor, Darkness,Tremor, Fine,Tremor, Intention,Tremor, Intermittent,Tremor, Massive,Tremor, Passive,Tremor, Persistent,Tremor, Pill Rolling,Tremor, Rest,Tremor, Resting,Tremor, Saturnine,Tremor, Senile,Tremor, Static,Tremors

Related Publications

Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
January 2014, Basic and clinical neuroscience,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
June 2015, Pharmacological reports : PR,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
May 2021, Neuroscience letters,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
May 2005, Pharmacology, biochemistry, and behavior,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
December 1971, Canadian journal of physiology and pharmacology,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
January 1972, Revue canadienne de biologie,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
June 2002, Neuroscience letters,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
January 1970, Confinia neurologica,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
June 2004, Brain research,
Pervin K Iseri, and Ayse Karson, and Kemal M Gullu, and Ozlem Akman, and Sibel Kokturk, and Melda Yardýmoglu, and Sarp Erturk, and Nurbay Ates
July 2012, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics,
Copied contents to your clipboard!