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Pregnancy in hamsters evoked a prompt increase in adrenal weight, with the highest value at day 5 and a subsequent fall toward the end of gestation. The surface densities of mitochondrial cristae and smooth endoplasmic reticulum did not display significant changes in the course of gestation, while 11 beta-hydroxylase and 3 beta-hydroxysteroid dehydrogenase/isomerase activity (two enzymes located in these two organelles) underwent significant increases at day 5 and day 10 of pregnancy, respectively. Neither the adrenal content of cortisol nor cortisol output by adrenal homogenates changed, but cortisol production measured in adrenal slices gradually rose during the course of pregnancy. Blood cortisol concentration increased about ten-fold toward the end of gestation, whereas the plasma ACTH level remained unchanged and plasma aldosterone concentration was significantly lowered. The conclusion is drawn that the pregnant hamster's adrenal glands possess an enhanced capacity to secrete cortisol, but the factor(s) involved remain unknown.
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1984,
Zeitschrift fur mikroskopisch-anatomische Forschung,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1984,
Zeitschrift fur mikroskopisch-anatomische Forschung,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1989,
In vivo (Athens, Greece),
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
May 1993,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1970,
Experimentelle Pathologie,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1995,
Endocrine research,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1987,
Experimental pathology,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
January 1973,
Acta endocrinologica. Supplementum,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
March 1962,
Vestnik dermatologii i venerologii,
M Nowak, and
G G Nussdorfer, and
K W Nowak, and
G Mazzocchi, and
L K Malendowicz
October 1958,
Khirurgiia,
