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DNA flow cytometric analysis and conventional clinical factors were compared with disease outcome in 257 patients with node-negative infiltrating ductal carcinoma who had been treated between 1976 and 1983. Median follow-up was 80 months; none of the patients received adjuvant therapy. The relative prognostic importance of clinical variables, ploidy, and S-phase fraction was analyzed by Cox multivariate analysis. Ploidy was analyzable for 198 tumors and did not predict survival. Nuclear grade predicted disease-free survival for all patients. For 71 patients with diploid tumors, only high S-phase had a statistically significant association with relapse. For 127 patients with aneuploid tumors, tumor diameter predicted both disease-free survival and cancer death; histologic grade was also significant for predicting disease-free survival. In conclusion, flow cytometric determination of ploidy and S-phase fraction can provide valuable predictive information in node-negative breast cancer in addition to conventional variables.
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D E Merkel
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The New England journal of medicine,
D J Winchester, and
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January 1993,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
D J Winchester, and
R B Duda, and
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D E Merkel
March 1989,
The New England journal of medicine,
D J Winchester, and
R B Duda, and
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September 1993,
Cancer,
D J Winchester, and
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January 1992,
Cancer investigation,
D J Winchester, and
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C Z August, and
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D M Wruck, and
A W Rademaker, and
D P Winchester, and
D E Merkel
December 1990,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
D J Winchester, and
R B Duda, and
C Z August, and
R A Goldschmidt, and
D M Wruck, and
A W Rademaker, and
D P Winchester, and
D E Merkel
October 1993,
Breast cancer research and treatment,
D J Winchester, and
R B Duda, and
C Z August, and
R A Goldschmidt, and
D M Wruck, and
A W Rademaker, and
D P Winchester, and
D E Merkel
December 2000,
Archives of surgery (Chicago, Ill. : 1960),
D J Winchester, and
R B Duda, and
C Z August, and
R A Goldschmidt, and
D M Wruck, and
A W Rademaker, and
D P Winchester, and
D E Merkel
May 1990,
Cancer,
D J Winchester, and
R B Duda, and
C Z August, and
R A Goldschmidt, and
D M Wruck, and
A W Rademaker, and
D P Winchester, and
D E Merkel
January 1992,
Journal of the National Cancer Institute. Monographs,
