-transparent.png){kind=logo}
Notch is a crucial cell signaling pathway in metazoan development. By means of cell-cell interactions, Notch signaling regulates cellular identity, proliferation, differentiation and apoptosis. Within the last decade, numerous studies have shown an important role for this pathway in the development and homeostasis of mammalian stem cell populations. Hematopoietic stem cells (HSCs) constitute a well-defined population that shows self-renewal and multi-lineage differentiation potential, with the clinically relevant capacity to repopulate the hematopoietic system of an adult organism. Here, we review the emergence, development and maintenance of HSCs during mammalian embryogenesis and adulthood, with respect to the role of Notch signaling in hematopoietic biology.
K V Pajcini, and
N A Speck, and
W S Pear
November 2005,
International journal of hematology,
K V Pajcini, and
N A Speck, and
W S Pear
November 2020,
Developmental dynamics : an official publication of the American Association of Anatomists,
K V Pajcini, and
N A Speck, and
W S Pear
September 2008,
Cell stem cell,
K V Pajcini, and
N A Speck, and
W S Pear
October 2014,
The EMBO journal,
K V Pajcini, and
N A Speck, and
W S Pear
December 2013,
Blood cells, molecules & diseases,
K V Pajcini, and
N A Speck, and
W S Pear
February 2014,
Blood,
K V Pajcini, and
N A Speck, and
W S Pear
January 2012,
Current topics in microbiology and immunology,
K V Pajcini, and
N A Speck, and
W S Pear
January 2017,
Current stem cell reports,
K V Pajcini, and
N A Speck, and
W S Pear
July 2017,
Experimental hematology,
K V Pajcini, and
N A Speck, and
W S Pear
January 2012,
Advances in experimental medicine and biology,
