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Polymorph migration stimulator (PMS) is a peptide factor produced by an in vitro reaction between glucocorticoids and human mononuclear phagocytes. This study was undertaken to determine the significance of the stimulatory effect of PMS on the capillary tube migration of human polymorphs. Colchicine, vinblastine and Nocodazole, all of which inhibit microtubular assembly, are shown to stimulate migration. Conversely, deuterium oxide which stabilizes microtubules inhibits migration. Increased intracellular cyclic AMP is associated with microtubular inhibition and isoprenaline, theophylline and dibutyryl cyclic AMP are also found to stimulate capillary tube migration. These results suggest that PMS acts by inhibiting the assembly of polymorph microtubules, an effect which may be mediated by cyclic AMP in the same manner as other peptide hormones.
R D Stevenson, and
A C Gray, and
N P Lucie
September 1973,
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie,
R D Stevenson, and
A C Gray, and
N P Lucie
January 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
R D Stevenson, and
A C Gray, and
N P Lucie
June 1976,
British medical journal,
R D Stevenson, and
A C Gray, and
N P Lucie
January 1970,
Acta dermato-venereologica,
R D Stevenson, and
A C Gray, and
N P Lucie
June 1979,
Bollettino della Societa italiana di biologia sperimentale,
R D Stevenson, and
A C Gray, and
N P Lucie
January 1986,
Transfusion,
R D Stevenson, and
A C Gray, and
N P Lucie
July 2008,
Journal of applied physiology (Bethesda, Md. : 1985),
R D Stevenson, and
A C Gray, and
N P Lucie
April 1975,
Annals of the rheumatic diseases,
R D Stevenson, and
A C Gray, and
N P Lucie
June 1979,
Bollettino della Societa italiana di biologia sperimentale,
R D Stevenson, and
A C Gray, and
N P Lucie
July 1995,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
