Biomaterial Database

Prochlorperazine in childhood: side-effects. 1977

D J Lankamp, and J Willemse, and S A Pikaar, and A N van Heyst

The side-effects of prochlorperazine (CompazineR StemetilR) were traced in thirty-six children up to the age of sixteen years and compared with those collected from literature. These side-effects appeared to be predominantly neurological and were independent of the dosage. Impaired consciousness, dyskinesia, pyramidal signs and hypertonus were the main neurological manifestations. Dyskinesia was the most frequent sign. These side-effects disappear spontaneously after discontinuation of the drug. Instant cure can be acquired by intra-muscular administration of orphenadrine (DisipalR).

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297	Male		Males
D009122	Muscle Hypertonia	Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.	Hypermyotonia,Muscular Hypertonicity,Hypertonia, Detrusor Muscle,Hypertonia, Infantile,Hypertonia, Neonatal,Hypertonia, Sphincter,Hypertonia, Transient,Muscle Tone Increased,Detrusor Muscle Hypertonia,Detrusor Muscle Hypertonias,Hypermyotonias,Hypertonia, Muscle,Hypertonias, Detrusor Muscle,Hypertonias, Infantile,Hypertonias, Muscle,Hypertonias, Neonatal,Hypertonias, Sphincter,Hypertonias, Transient,Hypertonicities, Muscular,Hypertonicity, Muscular,Increased, Muscle Tone,Infantile Hypertonia,Infantile Hypertonias,Muscle Hypertonia, Detrusor,Muscle Hypertonias,Muscle Hypertonias, Detrusor,Muscular Hypertonicities,Neonatal Hypertonia,Neonatal Hypertonias,Sphincter Hypertonia,Sphincter Hypertonias,Tone Increased, Muscle,Transient Hypertonia,Transient Hypertonias
D009422	Nervous System Diseases	Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.	Neurologic Disorders,Nervous System Disorders,Neurological Disorders,Disease, Nervous System,Diseases, Nervous System,Disorder, Nervous System,Disorder, Neurologic,Disorder, Neurological,Disorders, Nervous System,Disorders, Neurologic,Disorders, Neurological,Nervous System Disease,Nervous System Disorder,Neurologic Disorder,Neurological Disorder
D011346	Prochlorperazine	A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)	Compazine,Prochlorperazine Edisylate,Prochlorperazine Edisylate Salt,Prochlorperazine Maleate,Edisylate Salt, Prochlorperazine,Edisylate, Prochlorperazine,Maleate, Prochlorperazine,Salt, Prochlorperazine Edisylate
D011712	Pyramidal Tracts	Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts.	Corticobulbar Tracts,Corticospinal Tracts,Decussation, Pyramidal,Corticobulbar Tract,Corticospinal Tract,Pyramidal Decussation,Pyramidal Tract,Tract, Corticobulbar,Tract, Corticospinal,Tract, Pyramidal,Tracts, Corticobulbar,Tracts, Corticospinal,Tracts, Pyramidal
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003244	Consciousness Disorders	Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.	Consciousness, Level Altered,Disorder of Consciousness,Disorders of Consciousness,Semiconsciousness,Altered Level of Consciousness,Consciousness, Level Depressed,Depressed Level of Consciousness,Consciousness Disorder