The influence of the different morphological changes on gastric mucosa on somatostatin cell number in antrum mucosa and serum somatostatin. 2011

Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
J J Strossmayer University, Osijek University Hospital Center, Department of Gastroenterology and Hepatology, Osijek, Croatia. mihaljevic.silvio@kbo.hr

The aim of our paper was to investigate the influence of the different morphological changes on gastric mucosa on somatostatin D-cell number in antral mucosa and serum Somatostatin. We analyzed according to Sydney classification to what extent the severity of gastritis affect the observed hormonal values. somatostatin D-cell number in antral mucosa and serum Somatostatin values were compared between three groups of patients; mild, moderate and severe chronic gastritis. The average number of somatostatin cell in biopsy sample of antrum mucosa was 30.41 +/- 35.38 (N = 17) in the case of middle form, 18.69 +/- 26.65 (N = 56) in moderate and in severe case of chronic gastritis 5.23 +/- 5.93 (N = 7) cells in mm2 of mucosa. The level of somatostatin in the serum of middle form gastritis were 26.43 +/- 28.76, moderate 19.95 +/- 35.93 and severe 17.88 +/- 17.66 pg/mL. In order to determine the number of somatostatin cells in antrum mucosa and serum somatostatin with present morphological changes of mucosa, it might helpful to exclude the patients with non-ulcer dyspepsia, but with the higher risk of premalignant and malignant changes.

UI MeSH Term Description Entries
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D005756 Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders. Gastritides
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013004 Somatostatin A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Cyclic Somatostatin,Somatostatin-14,Somatotropin Release-Inhibiting Hormone,SRIH-14,Somatofalk,Somatostatin, Cyclic,Somatotropin Release-Inhibiting Factor,Stilamin,Somatostatin 14,Somatotropin Release Inhibiting Factor,Somatotropin Release Inhibiting Hormone
D015331 Cohort Studies Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics. Birth Cohort Studies,Birth Cohort Study,Closed Cohort Studies,Cohort Analysis,Concurrent Studies,Historical Cohort Studies,Incidence Studies,Analysis, Cohort,Cohort Studies, Closed,Cohort Studies, Historical,Studies, Closed Cohort,Studies, Concurrent,Studies, Historical Cohort,Analyses, Cohort,Closed Cohort Study,Cohort Analyses,Cohort Studies, Birth,Cohort Study,Cohort Study, Birth,Cohort Study, Closed,Cohort Study, Historical,Concurrent Study,Historical Cohort Study,Incidence Study,Studies, Birth Cohort,Studies, Cohort,Studies, Incidence,Study, Birth Cohort,Study, Closed Cohort,Study, Cohort,Study, Concurrent,Study, Historical Cohort,Study, Incidence
D019864 Somatostatin-Secreting Cells Endocrine cells found throughout the GASTROINTESTINAL TRACT and in islets of the PANCREAS. D cells secrete SOMATOSTATIN that acts in both an endocrine and paracrine manner. Somatostatin acts on a variety of tissues including the PITUITARY GLAND; gastrointestinal tract; pancreas; and KIDNEY by inhibiting the release of hormones, such as GROWTH HORMONE; GASTRIN; INSULIN; and RENIN. Pancreatic delta Cells,delta Cells,D Cells,Gastric D Cells,Gastric delta Cells,Pancreatic D Cells,Somatostatin Cells,D Cell,D Cell, Gastric,D Cells, Gastric,D Cells, Pancreatic,Gastric D Cell,Gastric delta Cell,Pancreatic D Cell,Pancreatic delta Cell,Somatostatin Cell,Somatostatin Secreting Cells,Somatostatin-Secreting Cell,delta Cell,delta Cell, Gastric,delta Cell, Pancreatic,delta Cells, Gastric,delta Cells, Pancreatic

Related Publications

Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
November 1977, Klinicheskaia khirurgiia,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
January 1987, Fiziologicheskii zhurnal,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
April 1963, Ceskoslovenska gastroenterologie a vyziva,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
January 2002, Likars'ka sprava,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
April 1992, Histology and histopathology,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
January 1972, Klinicheskaia meditsina,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
May 1978, Revista espanola de las enfermedades del aparato digestivo,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
April 1977, Klinicheskaia meditsina,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
February 1980, Wiener klinische Wochenschrift,
Silvio Mihaljević, and Miroslava Katicić, and Zeljko Krznarić, and Branko Dmitrović, and Ivan Karner, and Mario Stefanić, and Ljerka Pinotić, and Marina Samardzija, and Mirta Bensić
January 2006, Arkhiv patologii,
Copied contents to your clipboard!