Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice. 2011

Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Complementary DNA microarray analysis of human livers cannot exclude the influence of the immunological response. In this study, complementary DNA microarray analysis was performed under immunodeficient conditions with human hepatocyte chimeric mice, and gene expression profiles were analyzed by hepatitis B virus (HBV) infection and/or interferon treatment. The expression levels of 183 of 525 genes upregulated by interferon treatment were significantly suppressed in response to HBV infection. Suppressed genes were statistically significantly associated with the interferon signaling pathway and pattern recognition receptors in the bacteria/virus recognition pathway (P = 1.0 × 10(-8) and P = 1.2 × 10(-8), respectively). HBV infection attenuated virus recognition and interferon response in hepatocytes, which facilitated HBV escape from innate immunity.

UI MeSH Term Description Entries
D007108 Immune Tolerance The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. Immunosuppression (Physiology),Immunosuppressions (Physiology),Tolerance, Immune
D007372 Interferons Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. Interferon
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016513 Mice, SCID Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice. SCID Mice,SCID-hu Mice,Severe Combined Immunodeficient Mice,Immunodeficient Mice, Severe Combined,Mouse, SCID,Mouse, SCID-hu,Mice, SCID-hu,Mouse, SCID hu,SCID Mouse,SCID hu Mice,SCID-hu Mouse
D046228 Microarray Analysis The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format. Microarray Analytical Devices,Microarray Microchips,Nanoarray Analytical Devices,Analysis, Microarray,Analytical Device, Microarray,Analytical Device, Nanoarray,Analytical Devices, Microarray,Analytical Devices, Nanoarray,Device, Microarray Analytical,Device, Nanoarray Analytical,Devices, Microarray Analytical,Devices, Nanoarray Analytical,Microarray Analytical Device,Microarray Microchip,Microchip, Microarray,Microchips, Microarray,Nanoarray Analytical Device
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D057131 Immune Evasion Methods used by pathogenic organisms to evade a host's immune system. Evasion, Immune,Evasions, Immune,Immune Evasions

Related Publications

Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
June 2011, Gastroenterology,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
January 2022, Frontiers in microbiology,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
September 2018, BMC complementary and alternative medicine,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
March 2014, Human gene therapy. Clinical development,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
November 2017, Cellular and molecular gastroenterology and hepatology,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
August 2004, Bangladesh Medical Research Council bulletin,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
January 1986, Hepatology (Baltimore, Md.),
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
February 1979, Journal of clinical & laboratory immunology,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
October 2005, Biochemical and biophysical research communications,
Masataka Tsuge, and Shoichi Takahashi, and Nobuhiko Hiraga, and Yoshifumi Fujimoto, and Yizhou Zhang, and Fukiko Mitsui, and Hiromi Abe, and Tomokazu Kawaoka, and Michio Imamura, and Hidenori Ochi, and C Nelson Hayes, and Kazuaki Chayama
March 1991, Gastroenterology,
Copied contents to your clipboard!