Biomaterial Database

[Comparative effectiveness of mianserin and pyrazidol in endogenous depression]. 1990

S N Mosolov, and A I Sharov, and A D Kogan, and P V Ryvkin

Psychotropic activity of miansan (mianserin, lerivon) and pyrazidol was subjected to a comparative clinico-statistical study in depressions within the framework of phasically going endogenous psychoses. There were 2 clinically comparable groups each made up of 21 patients. Complete and appreciable efficacy was revealed in 16 patients (76.8%) receiving miansan and in 14 patients (67.2%) on pyrazidol. The general antidepressant effect of miansan correlated statistically significantly with sedative (anxiolytic and hypnotic) effect of the drug. As far as pyrazidol is concerned, the intensity of sedative and stimulating components of the antidepressant action did not essentially differ. No marked side effects were recorded even on drug administration in high doses, including persons with the signs of inferiority. The data obtained attest to the fact that miansan should be preferably used in anxious, anesthetic depressions and depressive paranoid conditions including those resistant to the preceding therapy with tricyclic antidepressants.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008803	Mianserin	A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.	Lerivon,Mianserin Hydrochloride,Mianserin Monohydrochloride,Org GB 94,Tolvon,Hydrochloride, Mianserin,Monohydrochloride, Mianserin
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D012074	Remission Induction	Therapeutic act or process that initiates a response to a complete or partial remission level.	Induction of Remission,Induction, Remission,Inductions, Remission,Remission Inductions
D002227	Carbazoles	Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D003866	Depressive Disorder	An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.	Depression, Endogenous,Depression, Neurotic,Depression, Unipolar,Depressive Syndrome,Melancholia,Neurosis, Depressive,Unipolar Depression,Depressions, Endogenous,Depressions, Neurotic,Depressions, Unipolar,Depressive Disorders,Depressive Neuroses,Depressive Neurosis,Depressive Syndromes,Disorder, Depressive,Disorders, Depressive,Endogenous Depression,Endogenous Depressions,Melancholias,Neuroses, Depressive,Neurotic Depression,Neurotic Depressions,Syndrome, Depressive,Syndromes, Depressive,Unipolar Depressions
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths