Evaluation of viral antibodies in Iranian multiple sclerosis patients. 2011

Mohsen Khaki, and Ali Ghazavi, and Keyvan Ghasami, and Mohammad Rafiei, and Mohammah-Ali Payani, and Ehsanollah Ghaznavi-Rad, and Ghasem Mosayebi
Department of Immunology and Microbiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

OBJECTIVE To evaluate the viral antibodies in new Iranian multiple sclerosis (MS) patients. METHODS In a cross-sectional study, sera from 61 MS patients and 60 healthy individuals were collected from January 2009 to March 2010 in the Immunology Department of Arak University of Medical Sciences, Arak, Iran, and examined for the presence of the anti-Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6), measles, mumps, and para-influenza viruses IgG and IgM using an enzyme-linked immunosorbent assay or immunofluorescence. RESULTS There were significant differences between the MS patients and the healthy individuals (controls) in the seroprevalence of anti-HHV-6 IgM (odds ratio [OR]=4.3, 95% confidence interval [CI]=2-9.3, p=0.001); anti-HHV-6 IgG (OR=2, 95% CI=1-4, p=0.04); anti-measles IgM (OR=3.2, 95% CI=1.5-6.9, p=0.002); and the anti-mumps IgM (OR=4.1, 95% CI=1.9-8.8, p=0.0001) and IgG (OR=9.5, 95% CI=3-29.6, p=0.0001). Almost all MS patients and the control individuals were negative to EBV and parainfluenza IgM. CONCLUSIONS These results confirm an association between the incidence of MS and the antibodies to HHV-6 and the measles and mumps viruses, and show induction of a primary immune response (IgM), or virus reactivation, in MS patients. These viruses may have an important role in development of MS as an initial trigger in this geographical area.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D007492 Iran A country bordering the Gulf of Oman, the Persian Gulf, and the Caspian Sea, between Iraq and Pakistan. The capital is Tehran. Islamic Republic of Iran
D008297 Male Males
D008459 Measles virus The type species of MORBILLIVIRUS and the cause of the highly infectious human disease MEASLES, which affects mostly children. Edmonston virus
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009109 Mumps virus The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection. Epidemic Parotitis Virus,Myxovirus parotitidis,Epidemic Parotitis Viruses,Mumps viruses
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D004854 Herpesvirus 4, Human The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies. Burkitt Herpesvirus,Burkitt Lymphoma Virus,E-B Virus,EBV,Epstein-Barr Virus,Human Herpesvirus 4,Infectious Mononucleosis Virus,Burkitt's Lymphoma Virus,HHV-4,Herpesvirus 4 (gamma), Human,Burkitts Lymphoma Virus,E B Virus,E-B Viruses,Epstein Barr Virus,Herpesvirus, Burkitt,Infectious Mononucleosis Viruses,Lymphoma Virus, Burkitt,Mononucleosis Virus, Infectious,Mononucleosis Viruses, Infectious

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