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[Quantification of fluorescein angiography in patients with non-arteritic anterior ischemic optic neuropathy]. 2011

T Hirsch, and A Remky, and N Plange, and M Kaup
Augenklinik des Universitätsklinikum Aachen, Aachen, Deutschland. Thalia.hirsch@gmail.com

OBJECTIVE The aim of this study was to evaluate the retinal hemodynamics and optic disc leakage by fluorescein angiography in patients with non-arteritic anterior ischemic optic neuropathy (NAION) and to correlate fluorescein angiography findings with the extent and topography of visual field loss. METHODS A total of 26 patients with acute NAION were included in the study. Fluorescein angiograms were performed by means of a scanning laser ophthalmoscope. The extent of early-phase optic disc leakage was assessed using a semiquantitative approach (focal versus diffuse type of leakage). Retinal arteriovenous passage (AVP) times were measured using dye dilution curves and digital image analysis for each hemisphere. The number of defective visual field points (StatPac: p<0.5%, uncorrected deviation plot) were evaluated (30/2 SITA, Humphrey-Zeiss) for the hemifields and different sectors. RESULTS In this study of patients with NAION the mean AVP was 1.79 s±0.43 which was not significantly correlated to the number of defective points. Furthermore, AVP was not significantly different in focal versus diffuse optic disc leakage. The number of defective points were not significantly different in focal versus diffuse leakage of the optic disc (p=0.57). CONCLUSIONS Retinal perfusion is not linked to the type and topography of disc leakage or the extent and topography of visual field damage in NAION. A global circulatory disorder e.g. due to a compartment syndrome of the optic nerve might account for these results.

UI MeSH Term Description Entries
D007090 Image Interpretation, Computer-Assisted Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease. Image Interpretation, Computer Assisted,Computer-Assisted Image Interpretation,Computer-Assisted Image Interpretations,Image Interpretations, Computer-Assisted,Interpretation, Computer-Assisted Image,Interpretations, Computer-Assisted Image
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010211 Papilledema Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175) Choked Disk,Edema of the Optic Disc,Edema of the Optic Disk,Optic Disc Edema,Optic Disk Edema,Optic Papilla Edema,Papillitis, Optic,Decreased Intraocular Pressure-Associated Papilledema,Increased Intracranial Pressure-Associated Papilledema,Optic Nerve Papillitis,Papilledema Associated with Decreased Intraocular Pressure,Papilledema Associated with Increased Intracranial Pressure,Papillitis,Retinal Edema,Choked Disks,Decreased Intraocular Pressure Associated Papilledema,Disk, Choked,Edema, Optic Disc,Edema, Optic Disk,Edema, Optic Papilla,Edema, Retinal,Edemas, Optic Disc,Edemas, Optic Disk,Edemas, Retinal,Increased Intracranial Pressure Associated Papilledema,Optic Papillitis,Papillitis, Optic Nerve,Retinal Edemas
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001783 Blood Flow Velocity A value equal to the total volume flow divided by the cross-sectional area of the vascular bed. Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D004395 Dye Dilution Technique Method for assessing flow through a system by injection of a known quantity of dye into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed) Dye Dilution Technic,Dilution Technic, Dye,Dilution Technics, Dye,Dilution Technique, Dye,Dilution Techniques, Dye,Dye Dilution Technics,Dye Dilution Techniques,Technic, Dye Dilution,Technics, Dye Dilution,Technique, Dye Dilution,Techniques, Dye Dilution
D005119 Extravasation of Diagnostic and Therapeutic Materials The escape of diagnostic or therapeutic material from the vessel into which it is introduced into the surrounding tissue or body cavity. Extravasation of Contrast Media,Extravasation of Diagnostic, Therapeutic Materials,Contrast Media Extravasation
D005260 Female Females

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