Biomaterial Database

[Clinical evaluation of fosfomycin]. 1990

C K Lan

Department of Internal Medicine, Chang Gung Memorial Hospital, Kaoshiung, R.O.C.

A total of 15 patients with a variety of infectious disease were treated with fosfomycin in Chang Gung Memorial Hospital, Kaoshiung. The drug was administered by iv drip infusion in doses of 204g per day for 5-28 days. The clinical response was satisfactory in 6 (100%) of 6 patients with urinary tract infection, 8 (80%) of 10 with septicemia and 1 with pneumonia. Overall, fosfomycin was effective in 13 (86%) of all patients treated. Except for 1 isolate of the pathogen, B. fragilis, and another 1 isolate of oxacillin-resistant Staphylococcus aureus, all the other 16 pathogens isolated, including Escherichia coli, Aeromonas, Klebsiella. Staphylococcus aureus, Acinetobacter, and Pseudomonas aeruginosa were successfully eradicated. Only 1 case developed skin rash. So fosfomycin is a useful agent and gram (-) organisms including oxacillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260	Female		Females
D005578	Fosfomycin	An antibiotic produced by Streptomyces fradiae.	Phosphonomycin,Fosfomycin Trometamol Salt,Fosfomycin Tromethamine,Monuril,Phosphomycin,Tromethamine, Fosfomycin
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D001424	Bacterial Infections	Infections by bacteria, general or unspecified.	Bacterial Disease,Bacterial Infection,Infection, Bacterial,Infections, Bacterial,Bacterial Diseases
D014552	Urinary Tract Infections	Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	Infection, Urinary Tract,Infections, Urinary Tract,Tract Infection, Urinary,Tract Infections, Urinary,Urinary Tract Infection