Biomaterial Database

[Initial experience with the use of monoclonal antibodies in the detection of cytomegalovirus early antigens in patients with transplants]. 1990

P Brůcek, and B Otová, and J Horácek

I. interní výzkumná základna, Institutu klinické a experimentální medicíny, Praha.

10 diabetics with kidney and pancreas transplantation (6) and with isolated kidney transplantation (4) underwent examination with the aim to produce evidence of cytomegalovirus excretion (CMV) by the urine. To prove the presence of CMV antigen, the authors used monoclonal antibody produced by DuPont. CMV was found to be present in the urine of 4 patients. The examination lasts max. 48 hrs. It yielded no evidence of interdependence between viruria and the serum levels of the CMV antibodies. Tests for CMV in biological material by means of monoclonal antibody is a modern and quick method which, unlike conventional virological procedures (serology, virus cultivation), plays an important part in clinical medicine.

UI	MeSH Term	Description	Entries
D003587	Cytomegalovirus	A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	Herpesvirus 5, Human,Human Herpesvirus 5,Salivary Gland Viruses,HHV 5,Herpesvirus 5 (beta), Human,Cytomegaloviruses,Salivary Gland Virus,Virus, Salivary Gland,Viruses, Salivary Gland
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000911	Antibodies, Monoclonal	Antibodies produced by a single clone of cells.	Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000956	Antigens, Viral	Substances elaborated by viruses that have antigenic activity.	Viral Antigen,Viral Antigens,Antigen, Viral
D016030	Kidney Transplantation	The transference of a kidney from one human or animal to another.	Grafting, Kidney,Renal Transplantation,Transplantation, Kidney,Transplantation, Renal,Kidney Grafting,Kidney Transplantations,Renal Transplantations,Transplantations, Kidney,Transplantations, Renal
D016035	Pancreas Transplantation	The transference of a pancreas from one human or animal to another.	Grafting, Pancreas,Transplantation, Pancreas,Graftings, Pancreas,Pancreas Grafting,Pancreas Graftings,Pancreas Transplantations,Transplantations, Pancreas
D017874	Immediate-Early Proteins	Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.	Proteins, Immediate-Early,Immediate Early Proteins,Proteins, Immediate Early