A study of ample postmortem case material of 25589 autopsies for a period of 25 years (1963-1987) revealed great diversity of the histologic forms of pancreas cancer both in males and in females, associated with numerous local complications (infiltration in adjacent organs). The major number of cases--144 (34.4 per cent of the total number) had histologic characteristics of adenocarcinoma: 88 cases in males (32.1 per cent) and 56 in females (38.6 per cent). Second in incidence--109 cases (26 per cent of the total number) had histologic characteristics of adenoscirrhous cancer--77 in males (28.1 per cent) and 32 in females (22.1 per cent). This is in keeping with the concept that adenocarcinoma is the most common from of pancreas cancer. The next most common forms are adenocarcinoma combined with nondifferentiated cancer, gelatinous carcinoma, adenoscirrhous with nondifferentiated scirrhous carcinoma, etc. An interesting fact is that the general trend of predominance of carcinoma of almost all histologic forms in males keeps on being valid. It is logical to expect that adenocarcinoma will keep on being the most common histologic form of pancreas cancer in the future.