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Purification of b4-2 sub-peak obtained on DEAE Sephadex A25 chromatography gave us the possibility of quantifying the plasma concentration of the neurotoxin present in uraemic patients with active polyneuropathy. From the purified neurotoxin isolated by kieselguhr and cellulose chromatography we calibrated analytic columns for b4-2 analysis. Plasma concentration, measured in 6 uraemic neuropathic patients, is between 13 and 19 mg/litre. In 52 uraemic patients without neuropathy, the plasma concentration is between 3 and 9 mg/litre. In 20 healthy subjects the plasma concentration is less than 1 mg/litre. The weekly neurotoxin removal in uraemic patients without neuropathy, treated by a five hours RP6 session 3 times a week, is of the same order of magnitude as the weekly urinary excretion in healthy subjects. Preliminary results of a tentative identification of this purified product indicate that it is not a polypeptide but an acid-polyol with carbohydrate structure.
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
January 1979,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
December 1978,
Scandinavian journal of clinical and laboratory investigation,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
June 1968,
Lancet (London, England),
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
October 1986,
Acta pharmacologica et toxicologica,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
January 1999,
Nephron,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
March 2000,
Nephron,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
February 1982,
Clinica chimica acta; international journal of clinical chemistry,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
January 1967,
Acta neurologica Scandinavica,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
March 2000,
Nephron,
N K Man, and
G Cueille, and
J Zingraff, and
T Drueke, and
P Jungers, and
A Sausse, and
J Boudet, and
J L Funck-Brentano
June 1979,
Annals of clinical research,
