Biomaterial Database

Adipocytokines, gut hormones and growth factors in anorexia nervosa. 2011

Irina Kowalska, and Monika Karczewska-Kupczewska, and Marek Strączkowski

Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Poland. irinak@poczta.onet.pl

Anorexia nervosa is a complex eating disorder of unknown etiology which affects adolescent girls and young women and leads to chronic malnutrition. Clinical manifestations of prolonged semistarvation include a variety of physical features and psychiatric disorders. The study of different biological factors involved in the pathophysiology of anorexia nervosa is an area of active interest. In this review we have described the role of adipocytokines, neurotrophins, peptides of the gastrointestinal system and growth factors in appetite regulation, energy balance and insulin sensitivity in anorexia nervosa patients.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000856	Anorexia Nervosa	An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)	Anorexia Nervosas,Nervosa, Anorexia,Nervosas, Anorexia
D054392	Adipokines	Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.	Adipocytokine,Adipocytokines,Adipokine
D054439	Ghrelin	A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.	Appetite-Regulating Hormone,GHRL Protein,Gastric MLTRP,Ghrelin Precursor,Ghrelin-Obestatin Preprohormone,Motilin-Related Peptide,Motilin-Related Peptide Precursor,Obestatin,PpMTLRP,Ppghrelin,Appetite Regulating Hormone,Ghrelin Obestatin Preprohormone,Motilin Related Peptide,Motilin Related Peptide Precursor,Peptide Precursor, Motilin-Related,Precursor, Ghrelin,Precursor, Motilin-Related Peptide
D036341	Intercellular Signaling Peptides and Proteins	Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.	Growth Factor,Growth Factors,Paracrine Peptide Factors,Paracrine Protein Factors,Factor, Growth,Factors, Growth,Peptide Factors, Paracrine