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Superoxide radicals, a species known to mobilize ferritin iron, and their interaction with catalytic iron have been implicated in the pathogenesis of alcohol-induced liver injury. The mechanism(s) by which ethanol metabolism generates free radicals and mobilizes catalytic iron, however, is not fully defined. In this investigation the role of hepatic aldehyde oxidase in the mobilization of catalytic iron from ferritin was studied in vitro. Iron mobilization due to the metabolism of ethanol to acetaldehyde by alcohol dehydrogenase was increased 100% by the addition of aldehyde oxidase. Iron release was favored by low pH and low oxygen concentration. Mobilization of iron due to acetaldehyde metabolism by aldehyde oxidase was completely inhibited by superoxide dismutase but not by catalase suggesting that superoxide radicals mediate mobilization. Acetaldehyde-aldehyde oxidase mediated reduction of ferritin iron was facilitated by incubation with menadione, an electron acceptor for aldehyde oxidase. Mobilization of ferritin iron due to the metabolism of acetaldehyde by aldehyde oxidase may be a fundamental mechanism of alcohol-induced liver injury.
S Shaw, and
E Jayatilleke
February 1986,
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S Shaw, and
E Jayatilleke
June 1982,
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S Shaw, and
E Jayatilleke
March 1991,
Plant physiology,
S Shaw, and
E Jayatilleke
June 2018,
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S Shaw, and
E Jayatilleke
May 2003,
Psychopharmacology,
S Shaw, and
E Jayatilleke
December 1975,
The Biochemical journal,
S Shaw, and
E Jayatilleke
October 1968,
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S Shaw, and
E Jayatilleke
January 2013,
Alcohol and alcoholism (Oxford, Oxfordshire),
S Shaw, and
E Jayatilleke
July 1995,
Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
S Shaw, and
E Jayatilleke
April 1987,
The Biochemical journal,
