In Vojvodina, Hepatitis A occurs endemoepidemiologically. The most intensive epidemiological process takes place in schools, so the specific morbidity of the age group of 7-14 years of age is 4.6 times greater in relation to the average value. The results of bacteriological investigation, as well as those carried out on the pulps of the fingers of pupils of all ages, indicate a high degree of fecal contamination of school environment both in urban and rural communities. The high incidence of asymptomatic infections (1:18), causes the late detection of epidemics, while the inadequate maintenance of personal and general hygiene makes their occurrence and spreading possible.