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Cytomegalovirus (CMV) retinitis is the most frequent ocular infection in AIDS, and it is responsible for blindness. Intravitreal injections of ganciclovir in doses of 400 g have been tried in patients who could not tolerate any systemic treatment. Induction therapy consists of 2 injections per week, followed by maintenance therapy with 1 injection per week. The present study involved 17 patients. Twenty-three induction courses could be evaluated; all had a favourable response with an average of 6 injections per eye. Seventeen maintenance courses were evaluated, with a mean of 5 injections per eye. There was no relapse in 10 eyes (70 percent) at 48 days. There was no evidence of toxicity from repeated intravitreal injections: no cataract, retinal detachment or endophthalmitis was observed with a total of 231 injections. Intravitreal ganciclovir appears to be an effective local treatment of CMV retinitis in AIDS patients when systemic therapy cannot be used.
I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
November 2005,
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I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
January 1996,
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I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
April 1996,
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I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
May 1988,
Ophthalmology,
I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
January 2019,
International journal of ophthalmology,
I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
January 1996,
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I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
January 1992,
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I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
August 1996,
Nippon Ganka Gakkai zasshi,
I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
July 1996,
American journal of ophthalmology,
I Cochereau-Massin, and
P Le Hoang, and
M Lautier-Frau, and
L Zazoun, and
P Marcel, and
M Robinet, and
A Besingue, and
F Rousselie
August 1992,
Ophthalmology,
