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A correlation between cyclic AMP (adenosine 3' : 5'-monophosphate) concentration within Leishmania cells and proliferation and transformation is demonstrated. By addition of dibutyryl cyclic AMP and cyclic AMP-phosphodiesterase inhibitors to the culture medium the intracellular level of cyclic AMP was increased. In the presence of 1mM caffeine the level of cyclic AMP accumulated in L. tropica promastigotes from 90 pmoles up to 380 pmoles per 10(9) cells, whereas the proliferation rate decreased to 50%. In the case of L. donovani the transformation of amastigotes to promastigotes was inhibited by addition of dibutyryl cyclic AMP as well as caffeine and papaverine. Especially caffeine (2mM) and papaverine (0.1mM) reduced the transformation rate to less than 5% after 48 h, compared to 35% of the control.
R D Walter, and
E Buse, and
F Ebert
January 1975,
Advances in metabolic disorders,
R D Walter, and
E Buse, and
F Ebert
August 1992,
International journal of oncology,
R D Walter, and
E Buse, and
F Ebert
September 1975,
Problemy gematologii i perelivaniia krovi,
R D Walter, and
E Buse, and
F Ebert
January 1980,
Cancer biochemistry biophysics,
R D Walter, and
E Buse, and
F Ebert
January 1973,
Virology,
R D Walter, and
E Buse, and
F Ebert
November 1975,
Bollettino dell'Istituto sieroterapico milanese,
R D Walter, and
E Buse, and
F Ebert
December 1972,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
R D Walter, and
E Buse, and
F Ebert
January 1974,
Advances in cancer research,
R D Walter, and
E Buse, and
F Ebert
February 1981,
Journal of cellular physiology,
R D Walter, and
E Buse, and
F Ebert
June 2002,
Annals of the New York Academy of Sciences,
