-transparent.png){kind=logo}
Biopsy specimens obtained from eight patients with lung cancer were tested for content of somatostatin receptors by autoradiography. Somatostatin receptors were detected in two of three patients with small cell lung cancer (SCLC) but in none of five patients with non-small cell lung cancer (NSCLC) including adenocarcinoma (two), squamous cell carcinoma (two), and bronchoalveolar carcinoma (one). In those with SCLC, specific somatostatin receptor binding was evidenced only in tumor foci and not in surrounding stroma or normal lung parenchyma. Further tissue characterization by immunoperoxidase staining with the pancytokeratin monoclonal antibody, mAB-lu-5, revealed labeling to all of the NSCLC but to none of the SCLC specimen. Selective immunoreactivity was detected in both the SCLC and the NSCLC specimen to chromogranin and neuron-specific enolase (NSE) whereas none of the specimen had detectable immunostaining to somatostatin, bombesin, serotonin, adrenocorticotropic hormone, neurofilament, calcitonin, and synaptophysin. The identification of somatostatin receptors in primary human lung cancer may have a bearing on the biology of this disease and perhaps on the clinical application of somatostatin analogues in patients with SCLC.
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
January 1993,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
January 1994,
Life sciences,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
January 1995,
Life sciences,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
July 2019,
Oncotarget,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
July 2008,
Clinical cancer research : an official journal of the American Association for Cancer Research,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
February 1990,
International journal of cancer,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
November 1992,
FEBS letters,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
August 1984,
British journal of cancer,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
January 1985,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
U Sagman, and
J B Mullen, and
K Kovacs, and
R Kerbel, and
R Ginsberg, and
J C Reubi
July 1997,
British journal of pharmacology,
