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Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular functions. The recently reported 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) is selectively phosphorylated by viral thymidine kinase but not by normal cellular thymidine kinase. Our present studies show that the acycloguanosine is as effective in treating herpetic keratitis in the rabbit as iododeoxyuridine and trifluorothymidine when given topically as an ointment. It is also effective when given intravenously for the treatment of herpetic iritis and is effective in preventing death from encephalitis in rabbits.
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
August 1983,
Antiviral research,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
May 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
May 1980,
Journal of virology,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
July 1982,
The American journal of medicine,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
December 1977,
Proceedings of the National Academy of Sciences of the United States of America,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
April 1978,
Nature,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
March 1988,
Chemical & pharmaceutical bulletin,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
January 1979,
Chemotherapy,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
December 1981,
Biochemical and biophysical research communications,
H E Kaufman, and
E D Varnell, and
Y M Centifanto, and
S D Rheinstrom
October 1979,
Analytical biochemistry,
