Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. 2011

Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.

OBJECTIVE The purpose of this report was to assess the link between macrophage polarization in epicardial adipose tissue and atherosclerosis in patients with coronary artery disease (CAD). BACKGROUND Macrophage accumulation enhances chronic inflammation in adipose tissue, but macrophage phenotypic change in human epicardial adipose tissue and its role in atherogenesis are unknown. METHODS Samples were obtained from epicardial and subcutaneous adipose tissue during elective cardiac surgery (CAD, n = 38; non-CAD, n = 40). Infiltration of M1/M2 macrophages was investigated by immunohistochemical staining with antibodies against CD11c and CD206, respectively. Expression of pro- and anti-inflammatory adipocytokines in adipose tissue was evaluated by real-time quantitative polymerase chain reaction. RESULTS Infiltration of macrophages and expression of pro- and anti-inflammatory cytokines were enhanced in epicardial fat of patients with CAD compared with that in non-CAD patients (p < 0.05). The ratio of M1/M2 macrophages was positively correlated with the severity of CAD (r = 0.312, p = 0.039). Furthermore, the expression of pro-inflammatory cytokines was positively correlated, and the expression of anti-inflammatory cytokines was negatively correlated with the ratio of M1/M2 macrophages in epicardial adipose tissue of CAD patients. By contrast, there was no significant difference in macrophage infiltration and cytokine expression in subcutaneous adipose tissue between the CAD and non-CAD groups. CONCLUSIONS The ratio of M1/M2 macrophages in epicardial adipose tissue of CAD patients is changed compared with that in non-CAD patients. Human coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008297 Male Males
D010496 Pericardium A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers. Epicardium,Fibrous Pericardium,Parietal Pericardium,Pericardial Cavity,Pericardial Space,Serous Pericardium,Visceral Pericardium,Cavities, Pericardial,Cavity, Pericardial,Pericardial Cavities,Pericardial Spaces,Pericardium, Fibrous,Pericardium, Parietal,Pericardium, Serous,Pericardium, Visceral,Pericardiums, Fibrous,Pericardiums, Serous,Serous Pericardiums,Space, Pericardial,Spaces, Pericardial
D011956 Receptors, Cell Surface Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands. Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D003324 Coronary Artery Disease Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause. Arteriosclerosis, Coronary,Atherosclerosis, Coronary,Coronary Arteriosclerosis,Coronary Atherosclerosis,Left Main Coronary Artery Disease,Left Main Coronary Disease,Left Main Disease,Arterioscleroses, Coronary,Artery Disease, Coronary,Artery Diseases, Coronary,Atheroscleroses, Coronary,Coronary Arterioscleroses,Coronary Artery Diseases,Coronary Atheroscleroses,Left Main Diseases
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000090323 Mannose Receptor A member of a family of endocytic receptors. Highly expressed on human macrophages, involved in regulating endocytosis, phagocytosis, and immune responses. CD206 Antigen,Cluster of Differentiation 206,MRC1 Protein,Mannose Receptors,Mannose-Fucose Receptor,Mannosyl-Fucosyl Receptor,Receptor, Mannose,206 Cluster, Differentiation,Antigen, CD206,Differentiation 206 Cluster,Mannose Fucose Receptor,Protein, MRC1,Receptor, Mannose-Fucose

Related Publications

Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
June 2017, Journal of cardiology,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
December 2019, Medical science monitor : international medical journal of experimental and clinical research,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
May 2020, Journal of cardiovascular pharmacology,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
December 2008, The American journal of cardiology,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
November 2012, Angiology,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
January 2023, Frontiers in cardiovascular medicine,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
October 2010, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
January 2018, PloS one,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
January 2014, International heart journal,
Yoichiro Hirata, and Minoru Tabata, and Hirotsugu Kurobe, and Tatsuo Motoki, and Masashi Akaike, and Chika Nishio, and Mayuko Higashida, and Hiroaki Mikasa, and Yutaka Nakaya, and Shuichiro Takanashi, and Takashi Igarashi, and Tetsuya Kitagawa, and Masataka Sata
March 2015, Anatolian journal of cardiology,
Copied contents to your clipboard!