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Simian retrovirus (SRV) serotypes 1 to 5 are exogenous type D viruses causing immune suppression in macaque monkeys. These viruses exhibit receptor interference with each other, with two endogenous type D viruses of the langur (PO-1-Lu) and squirrel monkey, and with two type C retroviruses, feline endogenous virus (RD114/CCC) and baboon endogenous virus (BaEV), indicating that each utilizes the same cell surface receptor (M. A. Sommerfelt and R. A. Weiss, Virology 176:58-69, 1990). Vesicular stomatitis virus pseudotype particles bearing envelope glycoproteins of RD114, BaEV, and the seven SRV strains were employed to detect receptors expressed in human-rodent somatic cell hybrids segregating human chromosomes. The only human chromosome common to all the susceptible hybrids was chromosome 19. By using hybrids retaining different fragments of chromosome 19, a provisional subchromosomal localization of the receptor gene was made to 19q13.1-13.2. Antibodies previously reported to be specific to a BaEV receptor (L. Thiry, J. Cogniaux-Leclerc, R. Olislager, S. Sprecher-Goldberger, and P. Burkens, J. Virol. 48:697-708, 1983) did not block BaEV, RD114, or SRV pseudotypes or syncytia. Antibodies to known surface markers determined by genes mapped to chromosome 19 did not block virus-receptor interaction. The identity of the receptor remains to be determined.
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B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
September 1993,
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M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
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M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
May 1985,
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M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
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M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
April 1992,
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M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
April 1987,
Virology,
M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
November 1989,
Virology,
M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
June 1985,
Science (New York, N.Y.),
M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
January 1990,
Cytogenetics and cell genetics,
M A Sommerfelt, and
B P Williams, and
A McKnight, and
P N Goodfellow, and
R A Weiss
January 1993,
Acta veterinaria Hungarica,
