Relationship between blood gas values and hormonal response to acute hypoxemia in fetal sheep. 1990

K Akagi, and J R Challis
Medical Research Council Group in Fetal and Neonatal Health and Development, Lawson Research Institute, St. Joseph's Health Centre, Department of Obstetrics and Gynecology, University of Western Ontario, London, Canada.

We examined the relationship of fetal plasma immunoreactive adrenocorticotropic hormone (IR-ACTH), arginine vasopressin (AVP) and cortisol to fetal arterial pO2 (PaO2), oxygen saturation (SaO2), change (delta) in PaO2 (delta PaO2) or SaO2 (delta SaO2) in fetal sheep at 125-139 days of gestational age. Fetal sheep were exposed to two levels of hypoxemia induced by altering the inspired percent oxygen to the mother for 1 h without fetal acidemia. Fetal carotid arterial IR-ACTH, AVP and cortisol concentrations during hypoxemia were correlated with fetal PaO2, SaO2, delta PaO2 and delta SaO2 by applying simple regression analysis. For IR-ACTH, a strong correlation was obtained with SaO2, delta SaO2 and delta PaO2 after log transformation to IR-ACTH. For AVP, strong correlation coefficients were obtained with delta SaO2, SaO2, delta PaO2 and PaO2 after reciprocal transformation to AVP, but for cortisol a strong correlation was obtained only with delta PaO2 after log transformation to cortisol. We conclude that during fetal hypoxemia without acidemia, there is a strong correlation between IR-ACTH and SaO2, delta SaO2, delta PaO2 but not PaO2, between AVP and delta SaO2, SaO2, delta PaO2, or PaO2, and between cortisol and delta PaO2.

UI MeSH Term Description Entries
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D010313 Partial Pressure The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Partial Pressures,Pressure, Partial,Pressures, Partial
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D002245 Carbon Dioxide A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D002339 Carotid Arteries Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery. Arteries, Carotid,Artery, Carotid,Carotid Artery
D005260 Female Females
D005316 Fetal Distress A nonreassuring fetal status (NRFS) indicating that the FETUS is compromised (American College of Obstetricians and Gynecologists 1988). It can be identified by sub-optimal values in FETAL HEART RATE; oxygenation of FETAL BLOOD; and other parameters. Nonreassuring Fetal Status,Fetal Status, Nonreassuring
D006854 Hydrocortisone The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations

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