BIOMAT Database Logo BIOMAT Database Logo

[Pure red cell aplasia induced by B19 parvovirus during allogeneic bone marrow transplantation]. 1990

H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Third Department of Internal Medicine, Akita University School of Medicine.

We report a patient who had abrupt onset of pure red cell aplasia (PRCA) induced by B19 parvovirus during allogeneic bone marrow transplantation (BMT). A 14-year-old girl with APL in complete remission was admitted in February 1988, for the purpose of BMT. She was received marrow from HLA identical sister on March 17, 1988 (day 0). She received 120 mg/kg cyclophosphamide and 12 Gy total body irradiation for conditioning of BMT. For graft-versus-host disease (GVHD) prophylaxis she was given cyclosporine and short term methotrexate. She did not develop acute GVHD after BMT, but on the day 28 a bone-marrow aspirate revealed findings of PRCA. During this course the number of white blood cell and platelet favorably recovered. B 19 parvovirus DNA was detected in the serum of the day 30 and day 42. Antihuman B 19 parvovirus (HPV) antibody titers were increased: the values of anti-HPV IgM were suddenly elevated and those of anti-HPV IgG were elevated. Serum on the day 42 inhibited erythroid progenitors (CFU-E, BFU-E) but not inhibited myeloid progenitors (CFU-C). A reticulocyte count recovered on the day 50. As the patient was HPV-IgG negative prior to BMT and the donor was HPV-IgG seronegative, the source of infection may be platelet transfusion (day 7 through 14).

UI MeSH Term Description Entries
D010322 Parvoviridae Infections Virus infections caused by the PARVOVIRIDAE. Parvovirus Infections,Infections, Parvoviridae,Infections, Parvovirus,Infection, Parvoviridae,Infection, Parvovirus,Parvoviridae Infection,Parvovirus Infection
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D012010 Red-Cell Aplasia, Pure Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Aplasia Pure Red Cell,Erythrocyte Aplasia,Pure Red-Cell Aplasia,Aplasia, Erythrocyte,Aplasia, Pure Red-Cell,Aplasias, Erythrocyte,Erythrocyte Aplasias,Pure Red Cell Aplasia,Pure Red-Cell Aplasias,Red Cell Aplasia, Pure,Red-Cell Aplasias, Pure
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D014184 Transplantation, Homologous Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals. Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D016026 Bone Marrow Transplantation The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION. Bone Marrow Cell Transplantation,Grafting, Bone Marrow,Transplantation, Bone Marrow,Transplantation, Bone Marrow Cell,Bone Marrow Grafting
D017713 Platelet Transfusion The transfer of blood platelets from a donor to a recipient or reinfusion to the donor. Blood Platelet Transfusion,Blood Platelet Transfusions,Platelet Transfusion, Blood,Platelet Transfusions,Platelet Transfusions, Blood,Transfusion, Blood Platelet,Transfusion, Platelet,Transfusions, Blood Platelet,Transfusions, Platelet
D065227 Transfusion Reaction Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility. Delayed Hemolytic Transfusion Reaction,Acute Hemolytic Transfusion Reaction,Blood Transfusion-Associated Adverse Reactions,Delayed Serologic Transfusion Reaction,Febrile Non-Hemolytic Transfusion Reaction,Hemolytic Transfusion Reaction,Hypotensive Transfusion Reaction,Post-Transfusion Purpura,Posttransfusion Purpura,TAGHD,Transfusion-Associated Allergic Reaction,Transfusion-Associated Circulatory Overload,Transfusion-Associated Dyspnea,Transfusion-Associated Graft Vs. Host Disease,Transfusion-Transmitted Infection,Allergic Reaction, Transfusion-Associated,Blood Transfusion Associated Adverse Reactions,Circulatory Overload, Transfusion-Associated,Circulatory Overloads, Transfusion-Associated,Dyspnea, Transfusion-Associated,Febrile Non Hemolytic Transfusion Reaction,Hemolytic Transfusion Reactions,Infection, Transfusion-Transmitted,Post Transfusion Purpura,Posttransfusion Purpuras,Purpura, Post-Transfusion,Purpura, Posttransfusion,Reaction, Hemolytic Transfusion,Reaction, Hypotensive Transfusion,Reactions, Hemolytic Transfusion,Transfusion Associated Allergic Reaction,Transfusion Associated Circulatory Overload,Transfusion Associated Dyspnea,Transfusion Associated Graft Vs. Host Disease,Transfusion Reaction, Hemolytic,Transfusion Reaction, Hypotensive,Transfusion Reactions,Transfusion Reactions, Hemolytic,Transfusion Reactions, Hypotensive,Transfusion Transmitted Infection,Transfusion-Associated Circulatory Overloads,Transfusion-Transmitted Infections

Related Publications

H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Pure red cell aplasia induced by B19 parvovirus during allogeneic bone marrow transplantation.
January 1989, Clinical transplants,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Pure red cell aplasia associated with parvovirus B19 infection occurring late after allogeneic bone marrow transplantation.
March 2004, American journal of hematology,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Long-term parvovirus B19 viraemia associated with pure red cell aplasia after allogeneic bone marrow transplantation.
September 2004, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Pure Red Cell Aplasia After Kidney Transplantation: Parvovirus B19 Culprit or Coincidence?
March 2019, Annals of transplantation,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Neutropenia in parvovirus B19-associated pure red cell aplasia.
August 2011, Annals of hematology,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Parvovirus B19–induced pure red cell aplasia in a heart transplant recipient.
October 2012, Blood,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
[Parvovirus B19-induced pure red cell aplasia in a liver transplant recipient].
December 2010, The Korean journal of laboratory medicine,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Pure red cell aplasia due to parvovirus B19 infection in solid organ transplantation.
August 1997, Clinical transplantation,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Successful re-transplantation in patient with recurrent parvovirus B19 pure red cell aplasia.
December 2019, Transplant infectious disease : an official journal of the Transplantation Society,
H Niitsu, and H Takatsu, and I Miura, and A Chubachi, and T Ito, and M Hirokawa, and Y Endo, and A Miura, and M Fukuda, and T Sasaki
Pure Red Cell Aplasia due to B19 Parvovirus Infection after Autologous Stem Cell Transplantation.
January 2011, Case reports in transplantation,
Copied contents to your clipboard!