BIOMAT Database Logo BIOMAT Database Logo

Novel roles of complement in T effector cell regulation. 2012

Peter S Heeger, and Claudia Kemper
Department of Medicine, Recanati Miller Transplant Institute and Immunology Institute, Mount Sinai School of Medicine, New York, USA.

Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immune modulation during a T cell response.

UI MeSH Term Description Entries
D003165 Complement System Proteins Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY). Complement Proteins,Complement,Complement Protein,Hemolytic Complement,Complement, Hemolytic,Protein, Complement,Proteins, Complement,Proteins, Complement System
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014181 Transplantation Immunology A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection. Immunology, Transplantation
D015551 Autoimmunity Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES. Autoimmune Response,Autoimmune Responses,Autoimmunities
D051916 Membrane Cofactor Protein A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a co-factor for their inactivation by COMPLEMENT FACTOR I. It also interacts with a wide variety of pathogens and mediates the immune response. Antigens, CD46,CD46 Antigens,CD46 Antigen,Trophoblast-Leukocyte Common Antigen,Antigen, CD46,Common Antigen, Trophoblast-Leukocyte,Trophoblast Leukocyte Common Antigen
D056704 Adaptive Immunity Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE). Acquired Immunity,Hybrid Immunity,Adaptive Immune Response,Adoptive Immunity,Immunity, Adaptive,Hybrid Immunities,Immune Response, Adaptive,Immunity, Acquired,Immunity, Adoptive,Immunity, Hybrid,Response, Adaptive Immune
D056724 Immunity, Humoral Antibody-mediated immune response. Humoral immunity is brought about by ANTIBODY FORMATION, resulting from TH2 CELLS activating B-LYMPHOCYTES, followed by COMPLEMENT ACTIVATION. Humoral Immune Response,Humoral Immune Responses,Humoral Immunity,Immune Response, Humoral,Immune Responses, Humoral,Response, Humoral Immune
D018417 Th1 Cells A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions. T Helper 1 Cells,TH-1 Cells,Type 1 Helper T Cells,Cell, TH-1,Cell, Th1,Cells, TH-1,Cells, Th1,TH 1 Cells,TH-1 Cell,Th1 Cell

Related Publications

Peter S Heeger, and Claudia Kemper
Novel roles for complement receptors in T cell regulation and beyond.
December 2013, Molecular immunology,
Peter S Heeger, and Claudia Kemper
Complement regulation of T-cell alloimmunity.
November 2013, Seminars in nephrology,
Peter S Heeger, and Claudia Kemper
Complement regulation of T cell immunity.
December 2012, Immunologic research,
Peter S Heeger, and Claudia Kemper
Complement regulation of T-cell alloimmunity.
February 2011, Current opinion in organ transplantation,
Peter S Heeger, and Claudia Kemper
Novel potential inhibitors of complement system and their roles in complement regulation and beyond.
October 2018, Molecular immunology,
Peter S Heeger, and Claudia Kemper
The role of complement in CD4⁺ T cell homeostasis and effector functions.
February 2013, Seminars in immunology,
Peter S Heeger, and Claudia Kemper
The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut.
March 2009, Mucosal immunology,
Peter S Heeger, and Claudia Kemper
Regulation of γδ T Cell Effector Diversification in the Thymus.
January 2020, Frontiers in immunology,
Peter S Heeger, and Claudia Kemper
Distinct regulation of effector and memory T-cell differentiation.
January 2008, Immunology and cell biology,
Peter S Heeger, and Claudia Kemper
Molecular regulation of effector and memory T cell differentiation.
December 2014, Nature immunology,
Copied contents to your clipboard!