BIOMAT Database Logo BIOMAT Database Logo

Protection of guinea-pigs against foot-and-mouth disease virus by immunization with a PhoE-FMDV hybrid protein. 1990

M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, The Netherlands.

A hybrid protein was constructed containing two antigenic determinants of the structural protein VP1 of foot-and-mouth disease virus, inserted in a cell surface-exposed region of Escherichia coli outer membrane protein PhoE. Immunization of guinea-pigs with partially purified protein resulted in high levels of neutralizing antibodies and complete protection against challenge with the virus.

UI MeSH Term Description Entries
D007114 Immunization Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow). Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D002213 Capsid The outer protein protective shell of a virus, which protects the viral nucleic acid. Capsids are composed of repeating units (capsomers or capsomeres) of CAPSID PROTEINS which when assembled together form either an icosahedral or helical shape. Procapsid,Prohead,Capsids,Procapsids,Proheads
D005536 Foot-and-Mouth Disease A highly infectious disease caused by FOOT AND MOUTH DISEASE VIRUS that affects mammals of the ARTIODACTYLA order (CATTLE; SHEEP; GOATS; and PIGS) and is characterized by high fever followed by the appearance of blisters inside the mouth and on the feet. Foot and Mouth Disease,Disease, Foot-and-Mouth,Diseases, Foot-and-Mouth,Foot-and-Mouth Diseases
D005537 Aphthovirus A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species. Equine rhinitis A virus,Equine rhinovirus 1,Aphthoviruses
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001425 Bacterial Outer Membrane Proteins Proteins isolated from the outer membrane of Gram-negative bacteria. OMP Proteins,Outer Membrane Proteins, Bacterial,Outer Membrane Lipoproteins, Bacterial
D018272 Porins Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES. Pore Protein,Pore Proteins,Porin,Protein, Pore,Proteins, Pore

Related Publications

M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Protection of guinea-pigs against foot-and-mouth disease by simultaneous inoculation of sendai virus and inactivated foot-and-mouth disease vaccine.
January 1972, Archiv fur die gesamte Virusforschung,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Protection of mice against challenge with foot and mouth disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1.
November 1999, Virology,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
[Protective immune response of guinea pigs against challenge with foot and mouth disease virus by immunization with foliar extracts from transgenic tomato plants expressing the FMDV structural protein VP1].
October 2006, Wei sheng wu xue bao = Acta microbiologica Sinica,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs.
February 2001, Vaccine,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Immunization of guinea pigs with foot-and-mouth disease virus subjected to photodynamic inactivation.
January 1966, Acta pathologica et microbiologica Scandinavica,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
[Immunization of pigs against foot-and-mouth disease with tissue culture virus--saponin vaccine].
September 1963, Deutsche tierarztliche Wochenschrift,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Intranasal immunization of guinea pigs with an immunodominant foot-and-mouth disease virus peptide conjugate induces mucosal and humoral antibodies and protection against challenge.
July 2003, Journal of virology,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Early protection of pigs against foot-and-mouth disease.
January 1974, The British veterinary journal,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease.
March 2007, Veterinary microbiology,
M Agterberg, and H Adriaanse, and S Barteling, and K van Maanen, and J Tommassen
ANTIBODIES PRODUCED BY GUINEA PIGS INFECTED WITH FOOT-AND-MOUTH DISEASE VIRUS.
June 1965, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!