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Fluorescence staining with rhodamine phalloidin specific for F-actin was employed to examine the effects of delta-9-tetrahydrocannabinol (THC) on the distribution of microfilaments in kangaroo rat epithelial cells (PtK2) and rabbit aortic endothelial cells (RAE). PtK2 cells were more sensitive to THC treatment than RAE cells. Exposure of PtK2 cells to 10 microM THC for 2 h disrupted the microfilament network. After treatment with 20 microM THC for 2 h there was a loss of cell-to-cell contact between PtK2 cells, and at 30 microM THC, the cells started to detach from the substratum. In contrast, microfilament disorganization but not cell detachment was observed in RAE cells at THC concentrations of 80 and 100 microM. The possible mechanisms which may account for the changes in the microfilament system are discussed.
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
November 1986,
Neuropharmacology,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
August 1975,
Research communications in chemical pathology and pharmacology,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
March 1976,
Clinical pharmacology and therapeutics,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
May 1975,
Clinical pharmacology and therapeutics,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
September 1979,
Research communications in chemical pathology and pharmacology,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
December 1983,
Brain research,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
March 1973,
Lebensversicherungs Medizin,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
September 2004,
Toxicon : official journal of the International Society on Toxinology,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
April 1993,
Neuropharmacology,
B W Kiosses, and
S K Tahir, and
V I Kalnins, and
A M Zimmerman
April 1979,
Life sciences,
