BIOMAT Database Logo BIOMAT Database Logo

Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma. 2011

Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. sonemasa@kuhp.kyoto-u.ac.jp.

BACKGROUND Adrenal venous sampling is the "gold standard" test in the diagnosis of an aldosterone-producing adenoma (APA) among patients with primary aldosteronism (PA) but is available only in specialized medical centers. Meanwhile, an APA is reported to be generally more sensitive to ACTH than idiopathic hyperaldosteronism. OBJECTIVE The aim was to evaluate the diagnostic accuracy of the ACTH stimulation test in the diagnosis of an APA among those with suspicion of PA. METHODS Fifty-nine patients admitted to Kyoto University Hospital on suspicion of PA were included in the study. METHODS ACTH stimulation tests with 1-mg dexamethasone suppression were performed. METHODS Plasma aldosterone concentrations (PAC) were examined every 30 min after ACTH stimulation. Receiver-operated characteristics curve analysis was used to evaluate the diagnostic accuracy. RESULTS PAC after ACTH stimulations were significantly higher in patients with an APA than in patients with idiopathic hyperaldosteronism or non-PA. Receiver-operated characteristics curve analyses showed that the PAC after ACTH stimulation was effective for the diagnosis of an APA among patients suspected of PA. The diagnostic accuracy was highest at 90 min after ACTH injection, with the optimal cutoff value greater than 37.9 ng/dl corresponding with sensitivity and specificity of 91.3 and 80.6% for the diagnosis of an APA. CONCLUSIONS Our study indicates that the ACTH stimulation test is useful in the diagnosis of an APA among patients suspected of PA. This test can be used to select patients who are highly suspected of an APA and definitely require adrenal venous sampling.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003907 Dexamethasone An anti-inflammatory 9-fluoro-glucocorticoid. Hexadecadrol,Decaject,Decaject-L.A.,Decameth,Decaspray,Dexasone,Dexpak,Hexadrol,Maxidex,Methylfluorprednisolone,Millicorten,Oradexon,Decaject L.A.
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006929 Hyperaldosteronism A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA. Aldosteronism,Conn Syndrome,Conn's Syndrome,Primary Hyperaldosteronism,Conns Syndrome,Hyperaldosteronism, Primary,Syndrome, Conn,Syndrome, Conn's
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000306 Adrenal Cortex Neoplasms Tumors or cancers of the ADRENAL CORTEX. Adrenocortical Cancer,Cancer of Adrenal Cortex,Adrenal Cortex Cancer,Cancer of the Adrenal Cortex,Neoplasms, Adrenal Cortex,Adrenal Cortex Cancers,Adrenal Cortex Neoplasm,Adrenocortical Cancers,Cancer, Adrenal Cortex,Cancer, Adrenocortical,Cancers, Adrenal Cortex,Cancers, Adrenocortical,Neoplasm, Adrenal Cortex
D000324 Adrenocorticotropic Hormone An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP). ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D000450 Aldosterone A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. Aldosterone, (+-)-Isomer,Aldosterone, (11 beta,17 alpha)-Isomer

Related Publications

Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
[The Value of Postural Stimulation Test Combined with Adrenal CT in the Diagnosis of Aldosterone-producing Adenoma].
January 2020, Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
Stimulation and suppression of aldosterone secretion in patients with an aldosterone-producing adenoma.
February 1969, The Journal of clinical endocrinology and metabolism,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test.
June 2019, Hypertension research : official journal of the Japanese Society of Hypertension,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
[Clinical value of captopril test in noninvasive diagnosis of aldosterone-producing adenoma].
December 2021, Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
[Aldosterone producing adenoma].
January 1993, Ryoikibetsu shokogun shirizu,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
An aldosterone-producing adrenal cortical adenoma.
September 1982, Anaesthesia,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
Quantitative energy spectrum CT in differential diagnosis of aldosterone-producing adenoma and cortisol-producing adenoma.
August 2023, Quantitative imaging in medicine and surgery,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
Expression and Histopathological Significance of Disabled-2 in Aldosterone-Producing Adenoma.
July 2017, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
[Diagnosis and therapy of aldosterone-producing adrenal gland adenoma].
April 1992, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
Takuhiro Sonoyama, and Masakatsu Sone, and Kazutoshi Miyashita, and Naohisa Tamura, and Kenichi Yamahara, and Kwijun Park, and Naofumi Oyamada, and Daisuke Taura, and Megumi Inuzuka, and Katsutoshi Kojima, and Kyoko Honda, and Yasutomo Fukunaga, and Naotetsu Kanamoto, and Masako Miura, and Akihiro Yasoda, and Hiroshi Arai, and Hiroshi Itoh, and Kazuwa Nakao
[Aldosterone-producing adrenal adenoma].
January 2000, Medicina,
Copied contents to your clipboard!