-transparent.png){kind=logo}
A group of twenty four workers handling di-isocyanates and with respiratory disease were investigated by occupational-type bronchial provocation tests for sensitivity to toluene di-isocyanate (TDI), to which all were exposed, and to diphenylmethane di-isocyanate (MDI) and hexamethylene di-isocyanate (HDI). Sixteen gave asthmatic reactions to TDI and eight of these also reacted to MDI. Four of the eight TDI and MDI reactors had histories of exposure only to TDI, and of them two reacted also to HDI. Of nine subjects tested with HDI, three gave asthmatic reactions, and all three also reacted to TDI and MDI. Thus reactions to MDI and HDI were elicited only in the TDI reactors. The possibility of specific sensitivity to these and other di-isocyanates requires tests in subjects exposed to them and not to TDI.
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
August 1977,
Clinical otolaryngology and allied sciences,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
April 1963,
Canadian Medical Association journal,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
February 1963,
The New England journal of medicine,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
January 1991,
International archives of occupational and environmental health,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
February 1966,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
March 1976,
Clinical allergy,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
August 1999,
Contact dermatitis,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
February 2003,
The Analyst,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
June 1977,
Occupational health; a journal for occupational health nurses,
I M O'Brien, and
M G Harries, and
P S Burge, and
J Pepys
February 1979,
Chest,
