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Total synthesis of a novel tetracyclic alkaloid, cassiarin F from the flowers of Cassia siamea. 2011
Jun Deguchi, and
Tomoe Hirahara, and
Shiori Oshimi, and
Yusuke Hirasawa, and
Wiwied Ekasari, and
Osamu Shirota, and
Toshio Honda, and
Hiroshi Morita
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Tokyo 142-8501, Japan.
A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum in vitro, was isolated from the flowers of Cassia siamea, and its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben-Hoesch type ring construction as key steps.
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