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This study was conducted to determine the effect of thyroid hormone on opiate receptor ligand-binding and pain sensitivity. Specific opiate receptor-binding was performed on brain homogenates of Swiss-Webster mice. There was a significant increase in 3H-naloxone-binding in thyroxine-fed subjects (hyperthyroid). Scatchard analysis revealed that the number of opiate receptors was increased in hyperthyroid mice (Bmax = 0.238 nM for hyperthyroid samples vs. 0.174 nM for controls). Binding affinity was unaffected (Kd = 1.54 nM for hyperthyroid and 1.58 nM for control samples). When mice were subjected to hotplate stimulation, the hyperthyroid mice were noted to be more sensitive as judged by pain aversion response latencies which were half that of control animals. After morphine administration, the hyperthyroid animals demonstrated a shorter duration of analgesia. These findings demonstrate that thyroxine increases opiate receptor number and native pain sensitivity but decreases the duration of analgesia from morphine.
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
January 1977,
Brain research bulletin,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
January 1981,
Neurobiology of aging,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
October 1984,
Journal of neurochemistry,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
August 1974,
Research communications in chemical pathology and pharmacology,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
August 1974,
Journal of medicinal chemistry,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
October 1985,
Yao xue xue bao = Acta pharmaceutica Sinica,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
October 1982,
Life sciences,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
August 1986,
Sheng li xue bao : [Acta physiologica Sinica],
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
March 1981,
Neurochemical research,
E A Edmondson, and
K A Bonnet, and
A J Friedhoff
June 1975,
The Journal of pharmacy and pharmacology,
