-transparent.png){kind=logo}
Chorionic villus biopsy specimens were studied electron microscopically in six pregnancies at risk of the infantile type of neuronal ceroid lipofuscinosis (INCL). The biopsy was performed in all cases in the first trimester of pregnancy (8-10 gestation weeks) by the transcervical route. In one case, the biopsy was repeated at 17 weeks by the transabdominal procedure. In two pregnancies, the endothelial cells and, to a lesser extent, the mesenchymal cells of the chorionic villi contained unit membrane-bound inclusions typical of INCL. In both cases, the pregnancy was terminated and in one of them identical inclusions were found in the brains and kidneys of the fetus at 20 weeks of gestational age. The children from the remaining four pregnancies are healthy and have shown no signs of the disease.
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
January 1995,
Brain & development,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
January 1988,
American journal of medical genetics. Supplement,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
October 1973,
Acta neuropathologica,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
March 1984,
The New England journal of medicine,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
February 2000,
Annals of neurology,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
April 1989,
Prenatal diagnosis,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
January 1994,
Pediatric pathology,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
July 1999,
Prenatal diagnosis,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
October 1974,
Developmental medicine and child neurology,
J Rapola, and
R Salonen, and
P Ammälä, and
P Santavuori
March 1978,
Neurology India,
