Biomaterial Database

Plasma lactic dehydrogenase in mice infected with Japanese encephalitis & West Nile viruses. 1990

S P Argade, and K Banerjee

National Institute of Virology, Pune.

A study of the total and isoenzymes fractions of lactic dehydrogenase (LDH) enzyme was carried out in the plasma of mice infected with Japanese encephalitis (JE) and West Nile (WN) viruses. Only 2 isoenzymes (LDH 4 and LDH 5) were present in control mice. There was a rapid increase of total LDH in the animals infected with the wild strain of viruses. Mice infected with wild strains of JE showed all 5 isoenzymes. LDH 1 disappeared after 12 days of infection but LDH 2 and LDH 3 persisted for 3 wk. The attenuated strain of JE did not produce any change either of the total content of the enzyme or of the isoenzyme pattern. In the plasma of mice infected with wild strains of WN viruses only 4 isoenzyme bands (LDH 2, 3, 4, 5) were detected. The LDH 3 persisted longer than LDH 2. With one strain of WN virus an extra band near LDH 4 was seen.

UI	MeSH Term	Description	Entries
D007527	Isoenzymes	Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.	Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D007770	L-Lactate Dehydrogenase	A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.	Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D004672	Encephalitis, Japanese	A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)	Encephalitis, Japanese B,Japanese Encephalitis,Japanese B Encephalitis,Japanese B Viral Encephalitis,Viral Encephalitis, Japanese B
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014901	West Nile Fever	A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)	Kunjin virus Infection,Encephalitis, West Nile Fever,WNV Infection,West Nile Fever Encephalitis,West Nile Fever Meningitis,West Nile Fever Meningoencephalitis,West Nile Fever Myelitis,West Nile Virus Infection,Infection, Kunjin virus,Infection, WNV,Kunjin virus Infections,WNV Infections
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus