Microphase separation in nonequilibrium biomembranes. 2011

Pierre Sens, and Matthew S Turner
Laboratoire Gulliver, UMR 7083 CNRS-ESPCI, Paris, France.

Compositional heterogeneities of cell membranes are thought to play an important role in many physiological processes. We study how variations in the membrane composition can be driven by nonthermal fluctuating forces and therefore show how these can occur relatively far from any critical point for the membrane. We show that the membrane steady state is not only controlled by the strength of the forces and how they couple to the membrane, but also by their dynamics: In a simple class of models this is captured by a single force correlation time. We conclude that the coupling of membrane composition to normal mechanical forces, such as might be exerted by polymerizing cytoskeleton filaments, could play an important role in controlling the steady state of a cell membrane that exhibits transient lateral modulations of its composition on length scales in the 10-100 nm regime.

UI MeSH Term Description Entries
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D003599 Cytoskeleton The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm. Cytoplasmic Filaments,Cytoskeletal Filaments,Microtrabecular Lattice,Cytoplasmic Filament,Cytoskeletal Filament,Cytoskeletons,Filament, Cytoplasmic,Filament, Cytoskeletal,Filaments, Cytoplasmic,Filaments, Cytoskeletal,Lattice, Microtrabecular,Lattices, Microtrabecular,Microtrabecular Lattices
D001696 Biomechanical Phenomena The properties, processes, and behavior of biological systems under the action of mechanical forces. Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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