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After repeated passages of herpes simplex type 1 (HSV-1) KOS virus in the presence of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) a mutant denoted PMEAr HSV-1 was isolated which grew well in the presence of 50-100 micrograms.ml-1 of the drug. PMEAr HSV-1 was still sensitive to the related phosphonate analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA). In fact, it was more susceptible to the action of HPMPA than the original virus. PMEAr HSV-1 also retained sensitivity to 5-bromo-2'-deoxyuridine and other, viral thymidine kinase-dependent substances such as (E)-5-(2-bromovinyl)-2'-deoxyuridine. However, PMEAr HSV-1 was much less sensitive to acyclovir, 1-(beta-D-arabinofuranosyl)cytosine and 1-(beta-D-arabinofuranosyl)thymine than the parental KOS virus.
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
January 1994,
Advances in experimental medicine and biology,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
July 1991,
Antiviral research,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
January 1996,
Pharmacy world & science : PWS,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
June 1993,
Antiviral research,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
September 1992,
Molecular pharmacology,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
November 1998,
Molecular pharmacology,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
January 1991,
Current eye research,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
November 1989,
Antimicrobial agents and chemotherapy,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
January 1991,
The Journal of biological chemistry,
V Vonka, and
E Anisimová, and
J Cerný, and
A Holý, and
I Rosenberg, and
I Votruba
January 1994,
Folia biologica,
