-transparent.png){kind=logo}
The asbestos fibers chrysotile and crocidolite cause a dose-dependent release of specific granule collagenase by human polymorphonuclear leukocytes (PMNL). Release of azurophil granule elastase was induced by the asbestos fibers at higher concentrations, suggesting that asbestos fibers primarily cause the release of specific granule contents of human PMNL. Wollastonite, a fibrous silicate mineral, causes a weaker collagenase release and no elastase release. The collagenase was released in inactive, latent form. Carboxymethyl cellulose (CMC), an agent known to blunt chrysotile-induced hemolysis and production of reactive oxygen metabolites by human PMNL, specifically inhibits chrysotile-induced release of collagenase. Chrysotile asbestos was found to bind the PMNL serine proteinase cathepsin G. A role of collagenase release, production of reactive oxygen metabolites and cathepsin G binding by chrysotile for the perpetuation of the asbestos-induced alveolitis is suggested.
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
October 1999,
Journal of biomedical materials research,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
February 1984,
Environmental research,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
January 1996,
Chemotherapy,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
October 1990,
Blood,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
March 1987,
Infection and immunity,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
January 1976,
Advances in prostaglandin and thromboxane research,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
March 1975,
Inflammation,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
January 1986,
Enzyme,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
August 1997,
FEBS letters,
M Hedenborg, and
T Sorsa, and
A Lauhio, and
M Klockars
January 1989,
Chemico-biological interactions,
