-transparent.png){kind=logo}
A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2',3'-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Numerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro.
Related Publications
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
January 1993,
Bulletin of mathematical biology,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
October 1989,
Biochemical and biophysical research communications,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
January 1992,
Laboratory investigation; a journal of technical methods and pathology,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
November 1996,
Journal of mathematical biology,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
August 1991,
Biotechnology and applied biochemistry,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
March 1995,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
January 1993,
Drug metabolism and disposition: the biological fate of chemicals,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
January 1991,
Journal of pharmaceutical sciences,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
August 1994,
Biochemical and biophysical research communications,
F Solimano, and
G I Bischi, and
M Bianchi, and
L Rossi, and
M Magnani
January 1995,
Life sciences,
