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The efficacy of different therapies and vaccine preparations was assessed for treating or preventing herpetic ocular keratitis induced by experimental inoculation in rabbits with two HSV-1 variants that display different pathogenetic potential. Early administration of acyclovir (ACV) promoted fast healing and prevented neurologic involvements: alpha-interferon (alpha-IFN) was less efficient than ACV; combined therapy with both drugs increased the antiviral effects. In an attempt to prevent the disease, rabbits were vaccinated with a slightly pathogenic HSV-1 variant or with a secreted form of an engineered HSV-1 glycoprotein gB (gB-1s) and were subsequently challenged with a highly pathogenic HSV-1 variant. Immunization of rabbits with gB-1s was much more efficient than immunization with live virus in reducing the severity of herpetic keratitis and in preventing CNS disease.
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Yan ke xue bao = Eye science,
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September 1979,
Investigative ophthalmology & visual science,
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October 2004,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
R Manservigi, and
C Incorvaia, and
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April 1987,
Current eye research,
R Manservigi, and
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September 1996,
Yan ke xue bao = Eye science,
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July 1991,
Antiviral research,
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February 2009,
Current eye research,
R Manservigi, and
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January 2008,
Klinische Monatsblatter fur Augenheilkunde,
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August 1966,
Nippon Ganka Gakkai zasshi,
R Manservigi, and
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January 1990,
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
