OBJECTIVE To report a case of Wells syndrome (eosinophilic cellulitis) in a patient who was previously hospitalized twice and received several antibiotic treatments. METHODS Inpatient hospital consultation. METHODS One patient diagnosed with Wells Syndrome based on supporting clinical history, histopathological examination, and other laboratory data. METHODS Change in signs and symptoms over time. RESULTS Improvement of skin lesions after administration of corticosteroids. CONCLUSIONS Wells syndrome is a clinical condition that mimics bacterial cellulitis. It is characterized as an erythematous, edematous tender plaque with predilection for the lower extremity. The authors report this case to warn clinicians about other primary dermatological disorders that resemble infectious cellulitis in order to avoid misdiagnoses and delayed treatment.