Biomaterial Database

Regional heterogeneity of right atrial repolarization. Monophasic action potential mapping in swine. 2011

Zhen Li, and Ying Liu, and Eva Hertervig, and Ole Kongstad, and Shiwen Yuan

Department of Arrhythmias, Skåne University Hospital, Lund University, Sweden.

OBJECTIVE To establish a set of reference values for regional dispersion of repolarization of the right atrium in the in situ heart of pigs and to see if the global dispersion of repolarization could be estimated from regional mapping. METHODS Monophasic action potential (MAP) were sequentially recorded from 28 ? 3 sites in seven different regional areas of the right atrium: lateral, anterior and posterior wall, septum, sinoatrial node (SAN), appendage, and near the tricuspid annulus (TA) in 10 healthy pigs using the CARTO mapping system. RESULTS The activation time (AT), MAP duration (MAPd) and end of repolarization time (EOR) of the whole right atrium were 68 ± 7, 239 ± 20 and 270 ± 23 ms, respectively. There were no significant differences on MAPd and EOR among the seven regional areas, nor between each of the regional and global values. The global dispersions of the MAPd and EOR were 75 ± 19 and 103 ± 13 ms, which were significantly greater than those obtained from any of the seven regional areas and those between two remote regions, SAN vs. TA and SAN vs. appendage regions. CONCLUSIONS The data of regional and global dispersion of repolarization in healthy pigs can serve as reference values for evaluation of increased dispersion of repolarization. The global dispersions of MAPd and EOR in the right atrium were poorly estimated from regional mapping, suggesting the importance of global mapping in evaluating the dispersion of atrial repolarization.

UI	MeSH Term	Description	Entries
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012849	Sinoatrial Node	The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).	Sinuatrial Node,Sinus Node,Sino-Atrial Node,Sinu-Atrial Node,Node, Sino-Atrial,Node, Sinoatrial,Node, Sinu-Atrial,Node, Sinuatrial,Node, Sinus,Nodes, Sino-Atrial,Nodes, Sinoatrial,Nodes, Sinu-Atrial,Nodes, Sinuatrial,Nodes, Sinus,Sino Atrial Node,Sino-Atrial Nodes,Sinoatrial Nodes,Sinu Atrial Node,Sinu-Atrial Nodes,Sinuatrial Nodes,Sinus Nodes
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014261	Tricuspid Valve	The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.	Tricuspid Valves,Valve, Tricuspid,Valves, Tricuspid
D016280	Atrial Function, Right	The hemodynamic and electrophysiological action of the RIGHT ATRIUM.	Right Atrial Function,Atrial Functions, Right,Function, Right Atrial,Functions, Right Atrial,Right Atrial Functions
D056969	Voltage-Sensitive Dye Imaging	Optical imaging techniques used for recording patterns of electrical activity in tissues by monitoring transmembrane potentials via FLUORESCENCE imaging with voltage-sensitive fluorescent dyes.	Action Potential Optical Mapping,Anatomic Electrical Activity Optical Mapping,Optical Action Potential Mapping,Optical Mapping, Action Potential,Optical Mapping, Anatomic Electrical Activity,Optical Mapping, Transmembrane Potential,Optical Transmembrane Potential Mapping,Optical Vm Mapping,Transmembrane Potential Optical Mapping,Imaging, Voltage-Sensitive Dye,Mapping, Optical Vm,Mappings, Optical Vm,Optical Vm Mappings,Vm Mapping, Optical,Vm Mappings, Optical,Voltage Sensitive Dye Imaging
D020517	Atrial Appendage	Ear-shaped appendage of either atrium of the heart. (Dorland, 28th ed)	Auricular Appendage,Heart Atrium Appendage,Atrium Appendage,Appendage, Atrial,Appendage, Atrium,Appendage, Auricular,Appendage, Heart Atrium,Appendages, Atrial,Appendages, Atrium,Appendages, Auricular,Appendages, Heart Atrium,Atrial Appendages,Atrium Appendage, Heart,Atrium Appendages,Auricular Appendages,Heart Atrium Appendages