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We studied the heterogeneity of myocardial blood flow in nine anesthetized closed-chest dogs using an indicator-dilution technique that allows the stochastic description of transport characteristics for three inert gases (helium, argon, and xenon) from the coronary inflow to outflow. The results show that under normal conditions the transcoronary transport of the tracers is spatially heterogeneous. Heterogeneity is strongly dependent on the arterial oxygen tension over a range of 40-200 Torr. This could be similarly observed with each tracer gas despite different physicochemical properties and was largely independent from the magnitude of coronary blood flow. The results are interpreted to mean that the arteriolar or intratissue PO2 influences myocardial blood flow over a broad range and possibly acts as an important integrating factor in the local regulation of coronary blood flow and flow reserve.
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
March 1985,
Cardiovascular research,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
January 1995,
Basic research in cardiology,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
August 1985,
Circulation research,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
January 2014,
Studies in health technology and informatics,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
February 2019,
Bulletin of experimental biology and medicine,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
June 1970,
Review of allergy,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
May 1975,
Investigative ophthalmology,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
January 2015,
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
September 1997,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
H G Wolpers, and
A Hoeft, and
H Korb, and
P R Lichtlen, and
G Hellige
January 1977,
Bibliotheca anatomica,
