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Multicenter, double-blind, placebo-controlled trial of triamcinolone acetonide nasal aerosol in the treatment of perennial allergic rhinitis. 1990
S Spector, and
E Bronsky, and
P Chervinsky, and
G Lotner, and
J Koepke, and
J Selner, and
D Pearlman, and
D Tinkelman, and
S Weakley, and
V Alderfer
Department of Clinical Research, Rorer Central Research, Horsham, PA 19044.
In a double-blind study involving 205 patients with perennial allergic rhinitis, statistically significantly greater symptomatic improvements were evident following the administration of 200 micrograms/day triamcinolone acetonide aerosol than following placebo. These improvements were evident as early as week 1 and were sustained throughout the 12-week study. They were accompanied by greater reductions in nasal eosinophils. Triamcinolone acetonide aerosol was well tolerated and had no effect on serum cortisol levels.
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