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The immunogenicity of Pandeflu subunit vaccine against influenza A/California/7/2009 (H1N1) was evaluated in 70 healthy volunteers aged 18 to 60 years. The vaccine was intramuscularly injected twice at an interval of 28 days. Each dose (0.5 ml) contains A(HIN1) influenza virus hemagglutinin (15 +/- 2.2 microg), aluminum hydroxide (Denmark) (0.475 +/- 0.075 microg), and the preservative thiomerosal (merthiolate) (50 +/- 7.5 microg). The level of antibodies was determined in the microneutralization assay. After administration of two doses of the vaccine at a 28-day interval, the geometric mean antibody titer (GMAT) reached 1:21.1 with a further increase to 1:30 (the baseline GMAT) was 1:6.1). The frequencies of seroconversion and seroprotection were 71.4 and 59.2%, respectively; the antibody increase factor was 4.92, which meets the CPMP criteria. The administration of the vaccine did not result in adverse reactions in the postvaccination period.
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M P Kostinov, and
N A Mikhailova, and
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O A Terkacheva, and
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A P Cherdantsev
September 2011,
The Journal of infectious diseases,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
January 2011,
Vaccine,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
January 2011,
Expert review of vaccines,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
January 2012,
The oncologist,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
January 2012,
Vaccine,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
January 2011,
PloS one,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
January 2010,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
November 2018,
Vaccine,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
June 2011,
Vaccine,
V V Zverev, and
M P Kostinov, and
N A Mikhailova, and
S N Zhirova, and
A N Mironov, and
O A Terkacheva, and
A A Romanova, and
A P Cherdantsev
October 2010,
Human vaccines,
